Completed Studies: Selected Prior Publications, Abstracts, and Research Trials

Sleep Medicine and Obstructive Sleep Apnea

• Ahmed M, Patel NP, Rosen I. Portable monitors in the diagnosis of obstructive sleep apnea. Chest. 2007 Nov;132(5):1672-7.
• Ahmed M, Patel NP, Rosen I. Split-night polysomnography. Chest. 2007 Nov;132(5):1664-71.
• Ahmed MM, Schwab RJ. Upper airway imaging in obstructive sleep apnea. Curr Opin Pulm Med. 2006 Nov;12(6):397-401.
• Punjabi NM, Ahmed MM, Polotsky VT, et al. Sleep-disordered breathing, glucose intolerance, and insulin resistance. Respir Physiol Neurobiol. 2003; 136(2-3):167–178.
• Sleep-Disordered Breathing in Patients with Thyroid Malignancy (MD Anderson Cancer Center, 2011–2012).
  • Analyzed polysomnography data for sleep-disordered breathing incidence in thyroid malignancy patients.
• Ahmed M, Punjabi NM. Association of Leptin with Nocturnal Desaturation in Patients with Sleep Apnea. Abstract presented at 2004 National Meeting of the American College of Physicians.
• Faruki S. Sleep-Disordered Breathing in Patients with Thyroid Malignancy. Retrospective chart review, MD Anderson Cancer Center, 2011–2012.
• Faruki S. Does the Higher Risk of Obstructive Sleep Apnea Hypopnea Syndrome Predict an Increased Length of Stay in the PACU? Retrospective analysis, University of Texas Health Science Center, 2011.

Pulmonary and Critical Care Medicine

• Ahmed MM, Schwab RJ. Chronic Non-Invasive Ventilation: Considerations During Sleep. Sleep Med Clin North Am. 2008 Dec;3(4):557-568.
• Ahmed MM, Lee FE. Understanding Nontypeable Haemophilus Influenzae and Chronic Obstructive Pulmonary Disease. Curr Opin Pulm Med. 2014 Mar;20(2):159-64.
• Ahmed M, Haponik E, Sevransky JE. Resident vasopressor selection in a university-based MICU. Abstract in Am J Respir Crit Care Med 2002;165(8) Suppl: A711.
• Farber HW, Walkey AJ, Alikhan M. The Role of Aldosterone in Pulmonary Venous Hypertension. Chest. 2010;137:502.
• Troponin I Elevations in Patients with Community-Acquired Pneumonia (Baylor College of Medicine, 2007–2009).
  • Retrospective study linking troponin I elevations with pneumonia outcomes.
• Alikhan M, Ieong M, Walkey AJ, Farber HW. Cardiopulmonary Exercise Testing with Right-Heart Catheterization in Patients with Systemic Sclerosis. J Rheumatol. 2010;37:1871–7.
• Alikhan M. Acute Pulmonary Embolism Admitted to the ICU: A Retrospective Analysis (The APEAR Analysis). Findings presented at the annual Pulmonary & Critical Care Research Symposium, 2014.
• Alikhan M, Honig E. Spontaneous Autobullectomy in a Patient with Severe COPD. Chest. 2012;142(4_MeetingAbstracts):3A.
• Waheed S, Gogineni S, Cunningham C, et al. Vital Capacity vs. Diaphragmatic Thickness in Patients with Bulbar and Spinal ALS. American Thoracic Society, 2021.
• Waheed S, Saeed A, Gogineni S, et al. Diaphragm Ultrasound Characteristics and Mortality in ALS Patients. American Thoracic Society, 2020.
• Clinical Trials
  • A Phase III, Randomized, Placebo-Controlled, Observer-Blinded Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent Vaccine When Administered as a 3-Dose Regimen in Healthy Young Adults Aged 18 to 26 Years.
  • A Phase III, Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults with Moderate or Severe Diabetic Foot Infections.

Vaccine Research and Immunology

• A Phase IV, Randomized, Double-Blind Trial to Evaluate the Immunogenicity and Safety of Pneumococcal Conjugate Vaccine When Administered Concomitantly with Seasonal Inactivated Influenza Vaccine in Adults 50 Years and Older.
• A Phase IV, Open-Label, Controlled, Multi-Center Study to Evaluate the 5-Year Antibody Persistence Among Children Who Previously Received Conjugate Vaccine at 2 to 10 Years of Age and to Assess the Immune Response to a Single Dose of Conjugate Vaccine.
• A Phase III, Stratified, Randomized, Observer-Blind, Controlled, Multicenter Clinical Study to Evaluate the Safety, Immunogenicity, and Efficacy of an Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine Compared to a Non-Adjuvanted Comparator Influenza Vaccine in Children 26 to <72 Months of Age.
• A Phase I Randomized, Multi-Center, Double-Blind, Placebo-Controlled, Dose-Response Study to Evaluate the Safety and Immunogenicity of the Ebola Vaccine Candidate in Healthy Adult Subjects.
• A Phase IV, Randomized, Double-Blind Trial to Evaluate the Immunogenicity and Safety of Pneumococcal Conjugate Vaccine When Administered Concomitantly with Seasonal Inactivated Influenza Vaccine in Adults 50 Years and Older Who Received One or More Doses of Pneumococcal Polysaccharide Vaccine before Study Enrollment.
• A Phase IV, Open-Label, Controlled, Multi-Center Study to Evaluate the 5-Year Antibody Persistence Among Children Who Previously Received Conjugate Vaccine at 2 to 10 Years of Age and to Assess the Immune Response to a Single Dose of Conjugate Vaccine.
• A Phase III, Stratified, Randomized, Double-Blind, Multicenter, Non-Inferiority Study to Evaluate the Safety and Immunogenicity of a Cell-Based Quadrivalent Subunit Influenza Virus Vaccine and Cell-Based Trivalent Subunit Influenza Virus Vaccines in Adults Ages 18 Years and Older.
• A Phase III, Randomized, Observer-Blind, Multicenter Study to Evaluate the Safety and Immunogenicity of Repeated Exposure to an Adjuvant Quadrivalent Subunit Influenza Virus Vaccine, Administered to Subjects Previously Vaccinated in Trial.
• A Phase I Randomized, Multi-Center, Double-Blind, Placebo-Controlled, Dose-Response Study to Evaluate the Safety and Immunogenicity of the Ebola Vaccine Candidate in Healthy Adult Subjects.
• Comparison of the Protective Efficacy of Quadrivalent versus Licensed Inactivated Vaccine in Healthy, Medically Stable Adults 2–50 Years of Age.
• Double-Blind, Randomized, Active-Controlled Comparison of the Immunogenicity and Safety of Quadrivalent versus in Healthy, Medically Stable Adults 18–49 Years of Age.
• A Phase II, Stratified, Randomized, Double-Blind, Multicenter, Non-Inferiority Study to Evaluate Safety and Immunogenicity of Cell-Based Quadrivalent Subunit Influenza Virus Vaccine and Cell-Based Trivalent Subunit Influenza Virus Vaccines in Subjects Ages 2 to <18 Years.
• Phase I Multi-Center, Observer-Blind, Randomized Dose-Ranging Study of Adjuvanted and Non-Adjuvanted Cell Culture-Derived, Inactivated Novel Swine Origin A/H3N2v Monovalent Subunit Influenza Virus Vaccine (H3N2c) in Children Ages 3 to 9 Years, Adolescents 9 to <18 Years, Adults 18 to <65 Years, and Elderly 65 Years and Older.
• A Phase III, Randomized, Placebo-Controlled, Observer-Blinded Trial to Assess the Safety, Tolerability, and Immunogenicity of Bivalent Vaccine When Administered as a 3-Dose Regimen in Healthy Young Adults Aged 18 to 26 Years.
• A Phase II, Randomized, Double-Blinded, Placebo-Controlled, Multiple-Arm, Parallel-Group, Adaptive Study to Investigate the Efficacy and Safety in Patients with Post-Myocardial Infarction Left Ventricular Dysfunction.
• A Phase III, Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults with Moderate or Severe Diabetic Foot Infections.
• Open Label, Multicenter Study in Healthy Children, Adults, and Elderly to Obtain Serum for Determination if Antibodies Induced by the 2014–2015 Quadrivalent Inactivated Influenza Vaccine Effectively Inhibit Currently Circulating Influenza Viruses.
• A Phase III, Stratified, Randomized, Observer-Blind, Controlled, Multicenter Clinical Study to Evaluate the Safety, Immunogenicity, and Efficacy of an Adjuvanted Quadrivalent Subunit Influenza Virus Vaccine Compared to a Non-Adjuvanted Comparator Influenza Vaccine in Children 26 to <72 Months of Age.
• A Phase III, Randomized, Active-Controlled, Observer-Blinded Trial to Assess the Lot Consistency, Safety, Tolerability, and Immunogenicity of a Meningococcal Serogroup B Bivalent Vaccine in Healthy Subjects Aged 10 to <19 Years.

Large-Scale Clinical Studies

• A Phase II, Stratified, Randomized, Double-Blind, Multicenter, Non-Inferiority Study to Evaluate Safety and Immunogenicity of Cell-Based Quadrivalent Subunit Influenza Virus Vaccine and Cell-Based Trivalent Subunit Influenza Virus Vaccines in Subjects Ages 2 to <18 Years.
• Phase I Multi-Center, Observer-Blind, Randomized Dose-Ranging Study of Adjuvanted and Non-Adjuvanted Cell Culture-Derived, Inactivated Novel Swine Origin A/H3N2v Monovalent Subunit Influenza Virus Vaccine (H3N2c).

Translational and Experimental Research

• Metabolism of Lipid-Derived Aldehyde, 4-Hydroxynonenal (HNE) in Human Epithelial Cells (UTMB, 2002).
  • Explored detoxification pathways of lipid peroxidation products in lens cells.
• Cellular Lipid Peroxidation End-Products Induce Apoptosis in Human Lens Epithelial Cells (UTMB, 2001).
  • Studied oxidative stress and apoptosis mechanisms in lens epithelial cells.
• Banina E, Kosov A, Muzaffar K, et al. Syncytiotrophoblast microparticles as a Pioneering Approach for Breast Cancer Prevention and Treatment.

Education and Scholarly Contributions

• Ahmed M, Schwab R. Pathogenesis of Obstructive Sleep Apnea: Insights from Upper Airway Imaging Studies. In Sleep Apnea: Pathogenesis, Diagnosis and Treatment.
• Bhusan V, Le T, O’Connell P, Ahmed M. First Aid for the USMLE Step III. McGraw-Hill Medical. 2005.